Sildenafil, sold first with the brand name Viagra in 1998 is a medication used to treat the symptoms of male sexual impotence problems. In addition, it is used to treat pulmonary arterial hypertension (high blood pressure in the blood vessels that supply the lungs). After 2013, when the patent of Viagra expired, other brands appeared using similar active ingredient to sildenafil, including brands such us Cialis, Revatio, Spedra, Levitra or Adcirca.
In general, it is taken by mouth and usually starts to work within 30 minutes, remaining active for about 4 hours.
One important factor causing erectile dysfunction is impaired circulation, which occurs naturally as we get older. Phosphodiesterase type 5 (PDE5) is an enzyme that promotes breakdown of cyclic guanosine monophosphate (cGMP). cGMP is a very important regulator which, among other things, regulates blood flow in the penis by mediating smooth muscle relaxation and resulting in penile erection.
Silnedafil belongs to a class of medications called PDE5 inhibitors and increases blood flow to the penis during sexual stimulation to help men get an erection by protecting cGMP from degradation by PDE5 in the corpus cavernosum, which contains most of the blood in the penis during an erection.
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